The purpose of this research is to improve human neurologic health and function through the integration of engineered devices into living systems. The research goal is to advance the field of Neural Engineering in three specific areas:
(i) Clinical implementation of devices in neural prosthesis systems for individuals with diseased or compromised neural systems. The specific research projects planned are (a) dynamic laryngotracheal closure and (b) implementation of peripheral nerve electrodes in clinical neuroprosthesis systems.
(ii) Advanced devices to improve extraction of information from and activation of the human nervous system. The specific research projects planned are (a) advanced Flat Interface Nerve Electrodes (FINE) with increased contact density, optimized contact layout, and inclusion of circuitry directly on the electrode and (b) investigation of non-linear, non-square stimulation paradigms for more selective peripheral nerve stimulation.
(iii) Neuromimetic interfaces between neural tissue and engineered devices. A neuromimetic interface is defined as an electrode, polymer, or other device or material that mimics the mechanical, chemical, and/or electrical properties of neural tissue. The purpose is to integrate devices that behave as though they were natural neural tissue. The specific research projects planned are (a) peripheral nerve electrodes coated with neural signaling molecules to produce axon collateral sprouting and transperineurial axon migration to connect to the electrode, and (b) polymeric fiber substrates with mechanical properties similar to neural tissue for use in cortical electrodes.
The research plan includes elements from basic, applied, and clinical research, or each phase of the "bench-to-bedside" process. It is envisioned to generate a pipeline of complementary research projects for development of neural prostheses.
- Harris JP, Capadona JR, Miller RH, Healy BC, Shanmuganathan K, Rowan SJ, Weder C, Tyler DJ.,Mechanically adaptive intracortical implants improve the proximity of neuronal cell bodies. J Neural Eng. 2011 Dec;8(6):066011. Epub 2011 Nov 2.
- Peterson EJ, Izad O, Tyler DJ. Predicting myelinated axon activation using spatial characteristics of the extracellular field. J Neural Eng. 2011 Aug;8(4):046030. Epub 2011 Jul 13.
- Harris JP, Hess AE, Rowan SJ, Weder C, Zorman CA, Tyler DJ, Capadona JR. In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes. J Neural Eng. 2011 Aug;8(4):046010. Epub 2011 Jun 8.
- Broniatowski M, Moore NZ, Grundfest-Broniatowski S, Tucker HM, Lancaster E, Krival K, Hadley AJ, Tyler DJ., Paced glottic closure for controlling aspiration pneumonia in patients with neurologic deficits of various causes, Ann Otol Rhinol Laryngol. 2010 Mar;119(3):141-9.
- Schiefer MA, Polasek KH, Triolo RJ, Pinault GC, Tyler DJ, Selective stimulation of the human femoral nerve with a flat interface nerve electrode, J Neural Eng., 2010 Mar 8;7(2):26006.
- Limnuson K, Tyler DJ, Mohseni P, Integrated electronics for peripheral nerve recording and signal processing, Conf Proc IEEE Eng Med Biol Soc., 2009:1639-42.
- Schiefer MA, Polasek KH, Triolo RJ, Pinault GC, Tyler DJ, Intraoperative demonstration of selective stimulation of the common human femoral nerve with a FINE, Conf Proc IEEE Eng Med Biol Soc., 2009:610-3.