Dustin Tyler, Ph.D. Associate Professor Office: Room 101 Wickenden Building Phone: (216)-368-0319 Fax: (216)-368-4872 Email: dxt23@case.edu Mail Address: Deliveries: Room 309 Wickenden Building 10900 Euclid Avenue Physical: Room 101, Wickenden Building 2071 Martin Luther King Jr. Drive Cleveland, OH 44106-7207

Office Hours

2013 Spring Office Hours: Wednesdays, 8:00am - 9:00 am, scheduled in 30 minutes blocks. Click here to reserve a time.

 

Selected Links 

• Functional Neural Interfaces Lab
• Advanced Platform Technology Center
• DJ Tyler PubMed Citations
• Functional Electrical Stimulation Center
• Louis Stokes Cleveland VA Medical Center Research
• Biography

 Research Summary

The purpose of this research is to improve human neurologic health and function through the integration of engineered devices into living systems.  The research goal is to advance the field of Neural Engineering in three specific areas:

(i) Clinical implementation of devices in neural prosthesis systems for individuals with diseased or compromised neural systems. The specific research projects ongoing are (a) dynamic laryngotracheal closure; (b) neural interfaces for amputee prostheses; and (c) implementation of peripheral nerve electrodes in functional restoration in individuals with spinal cord injury.

(ii) Advanced devices to improve extraction of information from and activation of the human nervous system. The specific research projects ongoing are (a) advanced Flat Interface Nerve Electrodes (FINE) with increased contact density, optimized contact layout, and inclusion of circuitry directly on the electrode; (b) investigation of genetic algorithms and high-density stimulation paradigms for more selective peripheral nerve stimulation; and (c) high-density interfascicular stimulation systems.

(iii) Neuromimetic interfaces between neural tissue and engineered devices. A neuromimetic interface is defined as an electrode, polymer, or other device or material that mimics the mechanical, chemical, and/or electrical properties of neural tissue. The purpose is to integrate devices that behave as though they were natural neural tissue. The specific research projects ongoing are (a) peripheral nerve electrodes combining electrical and optical stimulation techinques, and (b) polymeric fiber substrates with mechanical properties similar to neural tissue for use in cortical electrodes.

Recent Publications

1. Capadona, J. R., Tyler, D. J., Zorman, C. A., Rowan, S. J., & Weder, C. (2012). Mechanically adaptive nanocomposites for neural interfacing. MRS bulletin, 37(06), 581-589.
2. Fisher, Lee E., Dustin J. Tyler, and Ronald J. Triolo. "Optimization of selective stimulation parameters for multi-contact electrodes." Journal of neuroengineering and rehabilitation 10.1 (2013): 25.
3. Duke, Austin R., et al. "Hybrid electro-optical stimulation of the rat sciatic nerve induces force generation in the plantarflexor muscles." Journal of neural engineering 9.6 (2012): 066006
4. Broniatowski M, Grundfest-Broniatowski S, Hahn EC, Hadley AJ, Tyler DJ, Tucker HM, "Selective intraoperative stimulation of the human larynx." Laryngoscope. 2012 Aug 9, PMID:22886746.
5. Schiefer MA, Tyler DJ, Triolo RJ, "Probabilistic modeling of selective stimulation of the human sciatic nerve with a flat interface nerve electrode." J Comput Neurosci. 2012 Aug;33(1):179-90. Epub 2012 Jan 6. PMID: 22222951
6. Harris, James P., Jeffrey R Capadona, Robert H Miller, Brian C Healy, Kadhiravan Shanmuganathan, Stuart J Rowan, Christoph Weder, Dustin Tyler, “Mechanically adaptive intracortical implants improve the proximity of neuronal cell bodies,” J Neural Eng. 2011 Dec;8(6):066011. Epub 2011 Nov 2. PMID: 22049097.
7. Peterson, Erik J., Olivier Izad, Dustin Tyler, “Predicting axon activation using extracellular field shape characteristics,” J Neural Eng. 2011 Aug;8(4):046030. Epub 2011 Jul 13. PMID: 2175037.
8. Harris, James P., Allison E Hess, Stuart J Rowan, Christoph Weder, Christian A Zorman, Dustin J Tyler, and Jeffrey R Capadona, (2011) “In-vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes,” J Neural Engineering, 8(4):046010. PMID: 21654037
9. Hess, AE, JR Capadona, K Shanmuganathan, S J Rowan, C Weder, DJ Tyler, and CA Zorman, (2011) “Development of a stimuli-responsive polymer nanocomposite toward biologically-optimized, MEMS-based neural probes,” J of Micromechanics and Microengineering, 21:054009.
10. Schiefer MA, K Polasek, RJ Triolo, GCJ Pinault, DJ Tyler, (2010) “Selective Stimulation of the Human Femoral Nerve with a Flat Interface Nerve Electrode,” J Neural Eng, 7(2), PMID: 20208125.
11. J.R. Capadona, K. Shanmuganathan, DJ Tyler, S.J. Rowan, C. Weder, (2008) “Stimuli-responsive polymer nanocomposites inspired by the sea cucumber dermis”, Science, 319 (5868), 1370, PMID: 18323449.