Primary Faculty

Zheng-Rong Lu, Ph.D.


Zheng-Rong Lu, Ph.D.
M. Frank and Margaret Domiter Rudy Professor of Biomedical Engineering

Office: Room 427 Wickenden Building
Phone: (216)-368-0187
Fax: (216)-368-4969
Email: zxl125@case.edu
Mail Address: Room 309 Wickenden Building 2071 Martin Luther King Jr. Drive Cleveland, OH 44106-7207

Selected links:

• Department of Biomedical Engineering
Lu Research Group Site

Research Summary

Our laboratory focuses on molecular imaging and drug delivery using novel nanotechnology. We are interested in using biodegradable materials and organic nanomaterials to design and develop targeted, safe and effective imaging agents and drug delivery systems for diagnostic imaging, treatment of human diseases and image-guided therapy. Our ongoing research projects include 1) biodegradable macromolecular MRI contrast agents that can be used for contrast enhanced cardiovascular and cancer MRI; 2) targeted nanoglobules with well defined sizes (

Recent Publications

• 

T. Kaneshiro and Z.-R. Lu, Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier.  Biomaterials in press.

 
• 

Y. Feng, L. Emerson, E.-K. Jeong, DL Parker, Z.-R. Lu.  Non-invasive assessment of the efficacy of indocyanine green enhanced photothermal cancer therapy with dynamic contrast enhanced MRI using a biodegradable macromolecular contrast agent.  JMRI  In press.

 
• 

X.-L. Wang, R. Xu, X. Wu, D. Gillespie, R. Jensen, Z.-R. Lu.  Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice.  Molecular Pharmaceutics 2009, 6, 738-46.

 
• 

F. Ye, X. Wu, EK Jeong, D.L. Parker and Z.-R. Lu.  A peptide targeted contrast agent specific to fibrin-fibronectin complexes for cancer molecular imaging with MRI.  Bioconjugate Chemistry 2008, 19, 2300-3.

 
• 

T. Kaneshiro, EK Jeong, D.L. Parker and Z.-R. Lu. Synthesis and evaluation of globular Gd-DO3A conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolcules 2008, 9, 2742-8.

 
• 

Y. Feng, E.-K. Jeong, A. Mohs, L. Emerson, Z.-R. Lu. Characterization of tumor angiogenesis with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in mice.  MRM 2008, 60, 1347-52.

 
• 

A. Vaidya, Y. Sun, Y. Feng, L. Emerson, E.-K. Jeong, Z.-R. Lu.  Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer-drug conjugate.  Pharm. Res. 2008, 25, 2002-11

 
• 

Z.-R. Lu, F. Ye and A. Vaidya.  Polymer Platform for Drug Delivery and Biomedical Imaging. J. Control. Release 2007. 122, 269-77. 

 
• 

Z.-R. Lu, A.M. Mohs, Y. Zong and Y. Feng.  Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents.  Intl. J. Nanomed.  2006,1, 31-40. 


 



Located in Cleveland, Ohio, Case Western Reserve University is one of the nation's top research universities.
© Copyright Case Western Reserve University | Cleveland, Ohio 44106 | 216-368-2000 | info@case.edu | legal notice