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Zheng-Rong Lu, Ph.D. M. Frank and Margaret Domiter Rudy Professor of Biomedical Engineering
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Selected links:
• Department of Biomedical Engineering
• Lu Research Group Site
Research Summary
Our laboratory focuses on molecular imaging and drug delivery using novel nanotechnology. We are interested in using biodegradable materials and organic nanomaterials to design and develop targeted, safe and effective imaging agents and drug delivery systems for diagnostic imaging, treatment of human diseases and image-guided therapy. Our ongoing research projects include 1) biodegradable macromolecular MRI contrast agents that can be used for contrast enhanced cardiovascular and cancer MRI; 2) targeted nanoglobules with well defined sizes (
Recent Publications
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T. Kaneshiro and Z.-R. Lu, Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier. Biomaterials in press. |
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Y. Feng, L. Emerson, E.-K. Jeong, DL Parker, Z.-R. Lu. Non-invasive assessment of the efficacy of indocyanine green enhanced photothermal cancer therapy with dynamic contrast enhanced MRI using a biodegradable macromolecular contrast agent. JMRI In press. |
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X.-L. Wang, R. Xu, X. Wu, D. Gillespie, R. Jensen, Z.-R. Lu. Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice. Molecular Pharmaceutics 2009, 6, 738-46. |
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F. Ye, X. Wu, EK Jeong, D.L. Parker and Z.-R. Lu. A peptide targeted contrast agent specific to fibrin-fibronectin complexes for cancer molecular imaging with MRI. Bioconjugate Chemistry 2008, 19, 2300-3. |
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T. Kaneshiro, EK Jeong, D.L. Parker and Z.-R. Lu. Synthesis and evaluation of globular Gd-DO3A conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolcules 2008, 9, 2742-8. |
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Y. Feng, E.-K. Jeong, A. Mohs, L. Emerson, Z.-R. Lu. Characterization of tumor angiogenesis with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in mice. MRM 2008, 60, 1347-52. |
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A. Vaidya, Y. Sun, Y. Feng, L. Emerson, E.-K. Jeong, Z.-R. Lu. Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer-drug conjugate. Pharm. Res. 2008, 25, 2002-11 |
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Z.-R. Lu, F. Ye and A. Vaidya. Polymer Platform for Drug Delivery and Biomedical Imaging. J. Control. Release 2007. 122, 269-77. |
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Z.-R. Lu, A.M. Mohs, Y. Zong and Y. Feng. Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents. Intl. J. Nanomed. 2006,1, 31-40. |