|Efstathios (Stathis) Karathanasis, Ph.D.
• Department of Biomedical Engineering• Department of Radiology
• Case Center for Imaging Research• Case Comprehensive Cancer Cancer • Pubmed Citations
The Karathanasis Laboratory for Nanomedical Engineering focuses on translational cancer nanomedicine. Specifically, we exploit the engineerable nature of nanoparticle technology to develop clinically relevant therapeutic and imaging agents for hard-to-treat cancers based on the integration of nanotechnology, oncology, imaging science and cancer biology. Using robust in vitro, in silico and in vivo analyses, we study the relation between the physical characteristics of nanoparticles (size, shape, etc.) and the nanoparticle’s navigation through different biological processes to extract design parameters that improve the in vivo performance of nanoparticles. Furthermore, our research program develops nanoparticle imaging agents for MRI, CT, optical and molecular imaging to enable non-invasive in vivo interrogation at super-high resolutions and highly accurate diagnosis of disease. Our lab is located at University Hospitals Case Medical Center and is part of the Case Comprehensive Cancer Center and the Case Center for Imaging Research. To learn more about cancer and imaging research at Case, we encourage you to further explore the websites of our lab and its affiliiated centers.
- P.M. Peiris, R. Toy, A. Abramowski, P. Vicente; S. Tucci, L. Bauer, A. Mayer, M. Tam, E. Doolittle, J. Pansky, E. Tran, D. Lin, W.P. Schiemann, K.B. Ghaghada, M.A. Griswold, E. Karathanasis, Treatment of cancer micrometastasis using a multicomponent chain-like nanoparticle, Journal of Controlled Release (2013) doi: 10.1016/j.jconrel.2013.10.031
- R. Toy, P.M. Peiris, K.B. Ghaghada, E. Karathanasis, Shaping cancer nanomedicine: The effect of particle shape on the in vivo journey of nanoparticles, Nanomedicine (Lond) (2013) in press
- P.M. Peiris, M. Tam, P. Vicente, A. Abramowski, R. Toy, L. Bauer, A. Mayer, J. Pansky, E. Doolittle, S. Tucci, E. Schmidt, C. Shoup, S. Rao, K. Murray, R. Gopalakrishnan, R.A. Keri, J.P. Basilion, M.A. Griswold, E. Karathanasis, On-command drug release from nanochains inhibits growth of breast tumors, Pharmaceutical Research (2013) doi: 10.1007/s11095-013-1102-8
- R. Toy, E. Hayden, A. Camann, Z. Berman, P. Vicente, E. Tran, J. Meyers, J. Pansky, P. Peiris, H. Wu, A. Exner, D. Wilson, K. Ghaghada, E. Karathanasis, Multimodal In Vivo Imaging Exposes the Voyage of Nanoparticles in Tumor Microcirculation, ACS Nano 7(4) (2013) 3118-3129
- P. Peiris, R. Toy, E. Doolittle, J. Pansky, A. Abramowski, M. Tam, P. Vicente, E. Tran, E. Hayden, A. Camann, A. Mayer, B. Erokwu, Z. Berman, D. Wilson, H. Baskaran, C. Flask, R. Keri, E. Karathanasis, Imaging metastasis using an integrin-targeting chain-shaped nanoparticle. ACS Nano (2012) 8783-8795
- P. Peiris, L. Bauer, R. Toy, E. Tran, J. Pansky, E. Doolittle, E. Schmidt, E. Hayden, A. Mayer, R. Keri, M. Griswold, E. Karathanasis, Enhanced Delivery of Chemotherapy to Tumors Using a Multi-Component Nanochain with Radiofrequency-Tunable Drug Release, ACS Nano 6(5) (2012) 4157-4168